This course offers an advanced introduction to electron microscopy, emphasizing its physico-chemical foundations and practical applications relevant to drug innovation research.
Firstly, the course will focus on the fundamental interactions between electrons and matter.
Students will explore how these interactions determine image contrast, resolution, and signal generation across different electron microscopy techniques, including transmission and scanning modalities.
The course then examines technical aspects of electron sources and electron beam pathways, highlighting distinctions between transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Various detector systems will be discussed, with attention to the unique information each provides and its relevance to chemical, biological, and pharmaceutical samples. Microanalytical techniques, particularly energy-dispersive X-ray spectroscopy (EDX) coupled with both SEM and TEM, will be featured and contextualized with case studies.
Through lectures, demonstrations, and discussion of case studies, participants will gain a deep understanding of the mechanisms that govern electron scattering, diffraction, and energy loss, establishing a solid foundation for the interpretation and optimization of electron microscopy data in materials and life sciences.
- Docente: MilettoIvana